Mechanisms of Drug Tolerance

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New data emerging from the investigation of the death of Michael Jackson reveal that the iconic pop star was taking very high doses of sedative medications during the course of his career. At the time of his death, it was reported that he was taking at least ten tablets of the powerful sedative Xanax every night. Some report that this was an improvement over his previous ingestion of 30 to 40 tablets nightly. To the uninitiated, doses that high would be lethal. To someone who had developed a t

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